DEVELOPING NOVEL TREATMENTS FOR THE MOST SERIOUS CGD INFECTION: ASPERGILLUS
Professor Tom Rogers, Dr Elaine Bignell, Dr Ken Haynes & Professor
Arst Herb.
Imperial College Faculty of Medicine, London
£181,587 over 32 months Ended in 2003
This project studied the way in which the Aspergillus family of fungi can adapt
to changes in their growth environment and if this adaptive mechanism could be
an important factor in their ability to cause disease in CGD. The group identified
part of a pH dependent protein, which allows growth adaptation to acid and alkaline
conditions, as a potential drug anti-fungal drug target. It was shown that the
course of infection caused by Aspergillus can be very different in various models
of infection, and that performing experiments in a CGD model is vital to explore
the pathogenesis of infection.
Publications from CGD RT funded research - read more...
IMPORTANT NOTE :
The information contained on this website is intended only as a guideline, not as a substitute for medical advice. Always consult your doctor if you or your child has any CGD symptoms or concerns.
© 2001-2005 The Chronic Granulomatous Disorder (CGD)
Research Trust
Registered Charity No. 1003425 email:cgd@cgdrt.co.uk
The CGD Research Trust is a member of the Association of Medical Research Charities (AMRC), the Genetic Interest Group (GiG) and an associate member of the International Patient Organisation of Primary Immunodeficiencies (IPOPI)
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