UNDERSTANDING THE MECHANISM OF CGD AFFECTED CELLS
Professor Otto,
University of Twente, Holland
£59,000 over 1 year with proceeds from the 2004 appeal.
Basic understanding of how components of the enzyme that is affected in CGD
work together to help kill microbes is fundamental to developing new drug
treatments for CGD. This award is to continue the investigation of how the
enzyme, called NADPH oxidase, is assembled, activated and regulated at the
molecular level. This project will help shed light on how different mutations
in CGD affect the functioning of the enzyme. This may lead to the identification
of new therapeutic targets for regulating the enzyme and could lead to new
types of treatment for CGD.
IMPORTANT NOTE :
The information contained on this website is intended only as a guideline, not as a substitute for medical advice. Always consult your doctor if you or your child has any CGD symptoms or concerns.
© 2001-2005 The Chronic Granulomatous Disorder (CGD)
Research Trust
Registered Charity No. 1003425 email:cgd@cgdrt.co.uk
The CGD Research Trust is a member of the Association of Medical Research Charities (AMRC), the Genetic Interest Group (GiG) and an associate member of the International Patient Organisation of Primary Immunodeficiencies (IPOPI)
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